Mehrdad Shariati; Arash Esfandiari; Mehrdad Modarresi; Zahra Rahmani
Volume 19, Issue 1 , March and April 2012, , Pages 34-41
Abstract
Background: Extensive supply of herbal products in today’s societies in normal diet or as medications necessitates conduction of toxicological, histological, and hormonal studies. Awareness of the effects of medicinal plants and their inclusion in the diet can contribute to reproductive health. Since ...
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Background: Extensive supply of herbal products in today’s societies in normal diet or as medications necessitates conduction of toxicological, histological, and hormonal studies. Awareness of the effects of medicinal plants and their inclusion in the diet can contribute to reproductive health. Since Mentha pulegium is widely used in pharmaceutical and food industries due to its strong fragrance and beneficial therapeutic effects, this study examined the effects of hydro-alcoholic extract of Mentha pulegium leaves on the function of pituitary-testicular axis.
Materials and Methods: In this experimental study, 40 male rats of Wistar strain weighing about 190 220 g were divided into five groups of eight. The control group received nothing, the sham group received distilled water and ethanol, and the experimental groups received 400, 800, and 1600 mg/kg b.w. hydro-alcoholic extract of Mentha pulegium leaves intraperitoneally. The experiment period was 28 days.
Results: In this study, testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels showed a significant decrease compared to the control group. Furthermore, the number of spermatozoa and Leydig cells had declined in the experimental groups receiving the high dose of the extract. Histological examinations also revealed extensive degenerative changes in the germinal epithelium and spermatogenesis arrest in the experimental groups receiving the high dose of the extract.
Conclusion: Hydro-alcoholic extract of Mentha pulegium leaves in low dose had a significant decreasing effect on plasma total testosterone, FSH, and LH levels. The effects of this extract on histological changes of testis were dose-related.
Zeynab Amiri; Mehrdad Modaresi
Volume 18, Issue 1 , March and April 2011, , Pages 13-20
Abstract
Background and Purpose: Oxcarbazepine is a widely used novel antiepileptic drug. In vitro electrophysiologic studies indicate that oxcarbazepine can block voltage-sensitive sodium channels، enhance the functioning of the neural membranes، and inhibit the propagation of synaptic impulses. It is also ...
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Background and Purpose: Oxcarbazepine is a widely used novel antiepileptic drug. In vitro electrophysiologic studies indicate that oxcarbazepine can block voltage-sensitive sodium channels، enhance the functioning of the neural membranes، and inhibit the propagation of synaptic impulses. It is also necessary to investigate the effect of oxcarbazepine on sex hormones because of its effects on the nervous system and the close neuro-hormonal association of this system with reproduction. In this research، the effect of oxcarbazepine was studied on the amount LH، FSH، testosterone Hormones and male reproductive physiology.
Methods and Materials: This quasi-experimental research involved 40 adult male volunteers aging from 25 to 45 years old. They suffered from epilepsy and were selected from those admitted to the neurological clinics of Shiraz، Iran، and were assigned into four groups of 10: Control group receiving no materials، and experimental groups receiving 150، 300، and 600 mg/day oxcarbazepine as oral tablets for 30 days. The study was conducted upon the permit of the ethics committee and after the informed consent was signed by the participants. After the termination of this period، the levels of LH، FSH، and testosterone Hormones in the blood were measured. The obtained data were analyzed in SPSS 11.5 using Tukey، Duncan tests and ANOVA.
Results: According to the findings، plasma concentration of LH showed a significant increase (p